Zoladex (Goserelin) is a synthetic analogue (artificial copy) of the natural female hormone Gonadotrophin Releasing Hormone (GnRH) and is a GnRH agonist (works against). Zoladex is made by AstraZeneca.

How Zoladex works

Zoladex works by blocking the production of natural Follicle Stimulating Hormone (FSH) and Leutinising Hormone (LH), which are produced by the pituitary gland at the base of the brain. Without FSH and LH the ovaries will not produce oestrogen and the body is tricked into a pseudo (false) menopause. This will reduce the growth of the deposits of endometriosis and cause them to shrink. Zoladex reduces the symptoms of endometriosis including the pain.

N.B. During the early days of treatment with Zoladex, some women experience vaginal bleeding which usually stops without any treatment.

Administration and dosage of Zoladex

  • Zoladex comes as a single dose syringe applicator with 3.6mg depot injection (it slowly releases the drug over four weeks)
  • Zoladex is given as a single injection into the abdomen subcutaneously (under the skin) every four weeks
  • Zoladex can be started at any time during the monthly cycle and is given for a course of six months maximum
  • Zoladex is not suitable for the treatment of children

When Zoladex should not be used (contra-indications)

  • Pregnancy
  • Lactating women (breast feeding)
  • Known hypersensitivity to GnRH Analogues

Precautions in the use of Zoladex

  • Zoladex should not be used for more than one course of six months as it can cause loss of bone densit
  • Zoladex should be used with caution in women with known metabolic bone disease

Reaction of Zoladex with food/alcohol/drugs

No reactions with food, alcohol or drugs have been reported

Side effects of Zoladex

  • Hot flushes
  • Dry vagina
  • Mood changes
  • Headache
  • Sweating
  • Loss of sex drive
  • Depression
  • Change in breast size

The above side effects seldom require that the treatment be stopped.

Rarely, some women enter menopause during the treatment and their periods do not restart when treatment is stopped. This could happen if a woman is nearing the natural menopause. Zoladex may cause cramps/contractions of the cervix.

As with all treatments there may be no side effects at all, or there may be a few but it is rare to experience multiple side effects. Do remember to

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