Suprecur (Buserelin) is a hormone, produced synthetically. It is a peptide (a group of amino acid organic compounds) and has actions similar to Gonadotrophin Releasing Hormones (GnRH). Suprecur is licensed for the treatment of endometriosis as well as for the preparation programme for women awaiting In Vitro Fertilisation (IVF).

Suprecur is used in two different ways:

  • Nasal spray for endometriosis
  • Subcutaneous injection (injection just under the skin) for IVF preparation

How Suprecor works

Suprecur desensitises the pituitary gland in the brain to the action of natural GnRH. This reduces the production of the hormones – Follicle Stimulating Hormone (FSH) and Leutinising Hormone (LH). These hormones normally stimulate the ovaries to produce oestrogen and, as a result, the woman experiences a pseudo (false) menopause because the levels of oestradiol and progesterone circulating in the blood are lowered and the deposits of endometriosis shrink.

Administration and dosage of Suprecur

  • The nasal spray is a colourless solution and contains 150mcgs of Suprecur in one spray.
  • One spray is used in each nostril (i.e: 300mcgs) three times a day (usually morning, mid-day and evening).
  • Total daily dosage is 900mcgs.

It does not matter if the spray is used before or after meals, as long as it is used at regular intervals.
The spray is absorbed through the lining of the nose even if you have a cold. In these circumstances, blow your nose thoroughly before using the spray. If you are using decongestants for the treatment of a cold, the decongestant should be used at least thirty minutes after using the Suprecur spray.
The usual course of treatment is six months. It is advisable to have only one course of treatment at a time.
Suprecur is not suitable for the treatment of children or post-menopausal women.

When Suprecur should not be used (contra-indications):

  • Pregnancy
  • Lactating women (breast-feeding)
  • Undiagnosed vaginal bleeding
  • Hypersensitivity to Suprecur
  • Women with hormone dependant tumours
  • Hypersensitivity to GnRH
  • Hypersensitivity to Benzakonium (the preservative used in the spray)

Precautions in the use of Suprecur

Diabetic patients should be regularly monitored as Suprecur can interact with diabetic drugs.
Hypertensive patients should have regular blood pressure checks.
Patients who are known to suffer from depression should be checked regularly as Suprecur has been known to cause depression.
Oral contraceptives should be discontinued before starting treatment.

Side effects of Suprecur

The main side effects are a pseudo (false) menopause.

Commonly reported side effects:

  • Hot flushes
  • Increased sweating
  • Loss of libido
  • Withdrawal bleeding
  • Nose bleeds
  • Disturbance of smell
  • Changes in bone-density
  • Breakthrough bleeding
  • Dry vagina
  • Painful intercourse
  • Local nasal irritation
  • Hoarse voice
  • Disturbance of taste

Other reported side effects:

  • Headaches
  • Nausea
  • Dizzy spells
  • Vaginal discharge
  • Breast tenderness
  • Changes in breast size
  • Acne
  • Dry skin
  • Nails splitting
  • Vomiting
  • Stomach upsets
  • Swelling of face, arms and legs
  • Changes in body hair
  • Lack of concentration (avoid driving/machinery)
  • Dry sore eyes (especially in women with contact lenses)
  • Hypersensitivity reactions – redness of skin, rash, allergic asthma/breathing difficulties

As with all treatments, you may have no side effects at all, or you may have a few but it is rare to experience multiple side effects.
Do remember to report any side effects to your medical practitioner and ask for advice.

Notes on Suprecur

  • Make sure that you are not pregnant before starting treatment. A pregnancy test is advisable.
  • Barrier methods of contraception should be used during treatment, as Suprecur is not a contraceptive.
  • Periods generally return four to six weeks after completion of treatment.
  • It is advisable to have one period before trying for pregnancy.
  • Symptoms may return following treatment particularly in cases of severe disease, e.g: bowel, bladder, ureter, pouch of Douglas. Specialist surgical skills using resection are generally required to remove this.

See also

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