Dimetriose (Gestrinone) is made by Hoechst for the treatment of endometriosis.

What is Dimetriose?

Dimetriose is a synthetic (artificial) hormone and is an antiprogestin (it acts against the hormone progestin that is naturally present in women).

How Dimetriose works

Dimetriose is thought to work in two ways. It acts on the pituitary gland (gland situated at the base of the brain) by suppressing the production by the pituitary of Follicle Stimulating Hormone (FSH) and Leutinising Hormone (LH). These two hormones stimulate the ovaries to ovulate each month. If ovulation stops, the growth of endometriosis deposits should also stop. Dimetriose also works directly on the deposits of endometriosis suppressing their growth. Periods usually stop during treatment, but some spotting of blood may occur.

Administration and dosage of Dimetriose

Dimetriose comes in capsule form in the strength of 2.5mgs and one capsule is taken twice a week.
Dimetriose should be started on the first day of the monthly cycle to avoid exposing a pregnancy to the side effects of Dimetriose.
The second dose is taken three days later. Thereafter, Dimetriose should be taken at the same time on the same two days of the week for the duration of the treatment.
Dimetriose is normally taken for a course of six months.

What happens if a dose of Dimetriose is missed?

If one dose is missed, a capsule should be taken as soon as possible and the normal cycle resumed.
If two or more doses are missed, treatment should be stopped and re-started on the first day of the next period. A negative pregnancy test should be achieved before restarting the treatment.
Dimetriose is not suitable for the treatment of children or the elderly.

When Dimetriose should not be used (contra-indications)

  • Pregnancy
  • Heart disease
  • Kidney disease
  • Liver disease
  • Lactating women (breast feeding)
  • Circulatory problems during previous treatments with oestrogen or progesterone

Precautions in the use of Dimetriose

Diabetic patients should be regularly checked for their sugar and cholesterol levels.
Patients with high blood pressure need regular blood pressure checks as Dimetriose can cause fluid retention.
Make the medical practitioner aware if you have epilepsy.

Reaction of Dimetriose with food/alcohol/drugs

No reactions with food or alcohol have been reported.
Dimetriose taken with Rifampicin (a drug used for tuberculosis) and/or drugs used for epilepsy may result in an increase in the absorption of Dimetriose.

Side effects of Dimetriose

  • Acne
  • Oily skin
  • Spotting
  • Cramp
  • Headache
  • Depression
  • Nervousness
  • Weight gain
  • Dizziness
  • Fluid retention
  • Voice changes
  • Hot flushes
  • Gastric upsets
  • Increased hair growth (face/body)
  • Change in sex drive
  • Decreased breast size
  • Changes in appetite

As with all treatments, you may have no side effects at all, or you may have a few but it is rare to experience multiple side effects.
Do remember to report any side effects to your medical practitioner and ask for advice.

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